List of Publications

Publications in the following categories

Target identification and validation (61)

Drug discovery and development (46)

Quality in research, robustness of data (48)

Guidelines and recommendations (24)

Commercialisation, partnering with industry (11)

Safety and toxicity (13)

Other (5)

Abstracts/Posters (2)

By selecting several boxes you will get all publications which are relevant for the selected categories.

Publications

Target identification and validation

Andrade EL, Bento AF, Cavalli J, Oliveira SK, Freitas CS, Marcon R, Schwanke RC, Siqueira JM, Calixto JB. Non-clinical studies required for new drug development - Part I: early in silico and in vitro studies, new target discovery and validation, proof of principles and robustness of animal studies. Brazilian Journal of Medical and Biological Research (2016) Target identification and validation & Drug discovery and development Abstract PMID: 27783811

Bergauer T, Ruppert T, Essioux L, Spleiss O. Drug Target Identification and Validation: Global Pharmaceutical Industry Experts on Challenges, Best Strategies, Innovative Precompetitive Collaboration Concepts, and Future Areas of Industry Precompetitive Research and Development. Therapeutic Innovation & Regulatory Science (2016) Target identification and validation Abstract PMID: 30231745

Blagg J, Workman P. Chemical biology approaches to target validation in cancer. Current Opinion in Pharmacology (2014) Target identification and validation Abstract PMID: 25175311

Bunnage ME, Chekler ELP, Jones LH. Target validation using chemical probes. Nature Chemical Biology (2013) Target identification and validation PMID: 23508172

Bunnage ME. Getting pharmaceutical R&D back on target. Nature Chemical Biology (2011) Target identification and validation & Drug discovery and development PMID: 21587251

Carney S. Target validation. Drug Discovery Today (2012) Target identification and validation PMID: 22155225

Chen XP, Du GH. Target validation: A door to drug discovery. Drug Discoveries & Therapeutics (2007) Target identification and validation Abstract PMID: 22504361

Cook D, Brown D, Alexander R, March R, Morgan P, Satterthwaite G, Pangalos MN. Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework. Nature Reviews Drug Discovery (2014) Target identification and validation & Drug discovery and development Abstract PMID: 24833294

Cortés-Cros M, Schmelzle T, Stucke VM, Hofmann F. The path to oncology drug target validation: an industry perspective. Methods in Molecular Biology (2013) Target identification and validation Abstract PMID: 23436402

Dahlin JL, Inglese J, Walters MA. Mitigating risk in academic preclinical drug discovery. Nature Reviews Drug Discovery (2015) Target identification and validation & Drug discovery and development Abstract PMID: 25829283

Dai L, Li Z, Chen D, Jia L, Guo J, Zhao T, Nordlund P. Target identification and validation of natural products with label-free methodology: A critical review from 2005 to 2020. Pharmacology & Therapeutics (2020) Target identification and validation Abstract PMID: 32980441

Decher N, Netter MF, Streit AK. Putative impact of RNA editing on drug discovery. Chemical Biology & Drug Design (2013) Target identification and validation & Drug discovery and development Abstract PMID: 23253127

Ekert JE, Deakyne J, Pribul-Allen P, Terry R, Schofield C, Jeong CG, Storey J, Mohamet L, Francis J, Naidoo A, Amador A, Klein JL, Wendy Rowan. Recommended Guidelines for Developing, Qualifying, and Implementing Complex In Vitro Models (CIVMs) for Drug Discovery. SLAS Discovery (2020) Target identification and validation & Guidelines and recommendations Abstract PMID: 32495689

Frigault MM, Barrett JC. Is target validation all we need? Current Opinion in Pharmacology (2014) Target identification and validation Abstract PMID: 25261632

Gashaw I, Ellinghaus P, Sommer A, Asadullah K. What makes a good drug target? Drug Discovery Today (2012) Target identification and validation & Drug discovery and development Abstract PMID: 22155646

Gyertyán I. How can preclinical cognitive research further neuropsychiatric drug discovery? Chances and challenges. Expert Opinion on Drug Discovery (2020) Target identification and validation & Drug discovery and development Abstract PMID: 32183541

Hedstrom L. The Bare Essentials of Antibiotic Target Validation. ACS Infectious Diseases (2017) Target identification and validation Abstract PMID: 28081610

Hill AB. The environment and disease: association or causation? 1965. Journal of the Royal Society of Medicine (2015) Target identification and validation PMID: 25572993

Hoare SRJ, Fleck BA, Williams JP, Grigoriadis DE. The importance of target binding kinetics for measuring target binding affinity in drug discovery: a case study from a CRF1 receptor antagonist program. Drug Discovery Today (2019) Target identification and validation & Drug discovery and development Abstract PMID: 31557449

Hughes JP, Rees S, Kalindjian SB, Philpott KL. Principles of early drug discovery. British Journal of Pharmacology (2011) Target identification and validation & Drug discovery and development Abstract PMID: 21091654

Imming P, Sinning C, Meyer A. Drugs, their targets and the nature and number of drug targets. Nature Reviews Drug Discovery (2006) Target identification and validation Abstract PMID: 17016423

Ioerger TR, O'Malley T, Liao R, Guinn KM, Hickey MJ, Mohaideen N, Murphy KC, Boshoff HIM, Mizrahi V, Rubin EJ, Sassetti CM, Barry CE, Sherman DR, Parish T, Sacchettini JC. Identification of new drug targets and resistance mechanisms in Mycobacterium tuberculosis. PLoS One (2013) Target identification and validation Abstract PMID: 24086479

Jackson N, Czaplewski L, Piddock LJV. Discovery and development of new antibacterial drugs: learning from experience? Journal of Antimicrobial Chemotherapy (2018) Target identification and validation & Drug discovery and development Abstract PMID: 29438542

Jones LH. An industry perspective on drug target validation. Expert Opinion on Drug Discovery (2016) Target identification and validation PMID: 27111834

Kaelin WG. Common pitfalls in preclinical cancer target validation. Nature Reviews Cancer (2017) Target identification and validation Abstract PMID: 28524181

Koscielny G, An P, Carvalho-Silva D, Cham JA, Fumis L, Gasparyan R, Hasan S, Karamanis N, Maguire M, Papa E, Pierleoni A, Pignatelli M, Platt T, Rowland F, Wankar P, Bento AP, Burdett T, Fabregat A, Forbes S, Gaulton A, Gonzalez CY, Hermjakob H, Hersey A, Jupe S, Kafkas Ş, Keays M, Leroy C, Lopez FJ, Magarinos MP, Malone J, McEntyre J, Munoz-Pomer Fuentes A, O'Donovan C, Papatheodorou I, Parkinson H, Palka B, Paschall J, Petryszak R, Pratanwanich N, Sarntivijal S, Saunders G, Sidiropoulos K, Smith T, Sondka Z, Stegle O, Tang YA, Turner E, Vaughan B, Vrousgou O, Watkins X, Martin MJ, Sanseau P, Vamathevan J, Birney E, Barrett J, Dunham I. Open Targets: a platform for therapeutic target identification and validation. Nucleic Acids Research (2017) Target identification and validation Abstract PMID: 27899665

Lee JA, Berg EL. Neoclassic drug discovery: the case for lead generation using phenotypic and functional approaches. J Biomol Screen (2013) Target identification and validation & Drug discovery and development Abstract PMID: 24080259

Leslie BJ, Hergenrother PJ. Identification of the cellular targets of bioactive small organic molecules using affinity reagents. Chemical Society Reviews (2008) Target identification and validation Abstract PMID: 18568161

Lu Q, Livi GP, Modha S, Yusa K, Macarrón R, Dow DJ. Applications of CRISPR genome editing technology in drug target identification and validation. Expert Opinion on Drug Discovery (2017) Target identification and validation Abstract PMID: 28388235

Moore JD. The impact of CRISPR-Cas9 on target identification and validation. Drug Discovery Today (2015) Target identification and validation Abstract PMID: 25572406

Moustaqil M, Gambin Y, Sierecki E. Biophysical Techniques for Target Validation and Drug Discovery in Transcription-Targeted Therapy. International Journal of Molecular Sciences (2020) Target identification and validation Abstract PMID: 32225120

Mullard A. Reliability of 'new drug target' claims called into question. Nature Reviews Drug Discovery (2011) Target identification and validation PMID: 21878966

Murima P, McKinney JD, Pethe K. Targeting Bacterial Central Metabolism for Drug Development. Chemistry & Biology (2014) Target identification and validation Abstract PMID: 25442374

Ohlmeyer M, Zhou MM. Integration of small-molecule discovery in academic biomedical research. Mount Sinai Journal of Medicine: A Journal of Translational and Personalized Medicine (2010) Target identification and validation & Drug discovery and development Abstract PMID: 20687180

Overington JP, Al-Lazikani B, Hopkins AL. How many drug targets are there? Nature Reviews Drug Discovery (2006) Target identification and validation Abstract PMID: 17139284

Plata-Salamán CR, Ilyin SE. Considerations for target validation and industrial approaches. Methods in Molecular Biology (2007) Target identification and validation Abstract PMID: 17172719

Plenge RM. Disciplined approach to drug discovery and early development. Science Translational Medicine (2016) Target identification and validation & Drug discovery and development Abstract PMID: 27464747

Plenge RM, Scolnick EM, Altshuler D. Validating therapeutic targets through human genetics. Nature reviews. Drug Discovery (2013) Target identification and validation & Drug discovery and development Abstract PMID: 23868113

Plowright AT. Target Discovery and Validation: Methods and Strategies for Drug Discovery. Wiley‐VCH Verlag GmbH & Co. KGaA (2019) Target identification and validation Link

Prinz F, Schlange T, Asadullah K. Believe it or not: how much can we rely on published data on potential drug targets? Nature Reviews Drug Discovery (2011) Target identification and validation PMID: 21892149

Roberts RA. Understanding drug targets: no such thing as bad news. Drug Discovery Today (2018) Target identification and validation Abstract PMID: 29803936

Sams-Dodd F. Target-based drug discovery: is something wrong? Drug Discovery Today (2005) Target identification and validation & Drug discovery and development Abstract PMID: 15718163

Santos R, Ursu O, Gaulton A, Bento AP, Donadi RS, Bologa CG, Karlsson A, Al-Lazikani B, Hersey A, Oprea TI, Overington JP. A comprehensive map of molecular drug targets. Nature Reviews Drug Discovery (2017) Target identification and validation Abstract PMID: 27910877

Settleman J, Sawyers CL, Hunter T. Challenges in validating candidate therapeutic targets in cancer. eLife (2018) Target identification and validation Abstract PMID: 29417929

Silver LL. Appropriate Targets for Antibacterial Drugs. Cold Spring Harbor Perspectives in Medicine (2016) Target identification and validation Abstract PMID: 27599531

Silver LL. Challenges of antibacterial discovery. Clinical Microbiology Reviews (2011) Target identification and validation Abstract PMID: 21233508

Silver LL. Multi-targeting by monotherapeutic antibacterials. Nature Reviews Drug Discovery (2007) Target identification and validation Abstract PMID: 17159922

Sim DS, Kauser K. In Vivo Target Validation Using Biological Molecules in Drug Development. New Approaches to Drug Discovery. Handbook of Experimental Pharmacology (2016) Target identification and validation & Drug discovery and development Abstract PMID: 26552401

Singh NK, Selvam SM, Chakravarthy P. T-iDT : tool for identification of drug target in bacteria and validation by Mycobacterium tuberculosis. In Silico Biology (2006) Target identification and validation Abstract PMID: 17518759

Sioud M. Main approaches to target discovery and validation. Methods in Molecular Biology (2007) Target identification and validation Abstract PMID: 17172722

Smith C. Drug target validation: Hitting the target. Nature (2003) Target identification and validation PMID: 12646927

Stefaniak J, Huber KVM. Importance of Quantifying Drug-Target Engagement in Cells. ACS Medicinal Chemistry Letters (2020) Target identification and validation Abstract PMID: 32292539

Stock JK, Jones NP, Hammonds T, Roffey J, Dillon C. Addressing the right targets in oncology: challenges and alternative approaches. Journal of Biomolecular Screening (2015) Target identification and validation Abstract PMID: 25614505

Surade S, Blundell TL. Structural biology and drug discovery of difficult targets: the limits of ligandability. Chemistry & Biology (2012) Target identification and validation & Drug discovery and development Abstract PMID: 22284353

Sweis RF. Target (In)Validation: A Critical, Sometimes Unheralded, Role of Modern Medicinal Chemistry. ACS Medicinal Chemistry Letters (2015) Target identification and validation Abstract PMID: 26101559

Thomsen SK, Gloyn AL. Human genetics as a model for target validation: finding new therapies for diabetes. Diabetologia (2017) Target identification and validation Abstract PMID: 28447115

Vandamme D, Minke BA, Fitzmaurice W, Kholodenko BN, Kolch W. Systems biology-embedded target validation: improving efficacy in drug discovery. WIREs Systems Biology and Medicine (2014) Target identification and validation Abstract PMID: 24214316

Vasaikar S, Bhatia P, Bhatia PG, Chu Yaiw K. Complementary Approaches to Existing Target Based Drug Discovery for Identifying Novel Drug Targets. Biomedicines (2016) Target identification and validation Abstract PMID: 28536394

Vennemann M, Ruland V, Kruse J-P, Harloff C, Trübel H, Gielen-Haertwig H. Future unmet medical need as a guiding principle for pharmaceutical R&D. Drug Discovery Today (2019) Target identification and validation & Drug discovery and development Abstract PMID: 31233729

Wendler A, Wehling M. The translatability of animal models for clinical development: biomarkers and disease models. Current Opinion in Pharmacology (2010) Target identification and validation & Drug discovery and development Abstract PMID: 20542730

Wyatt PG, Gilbert IH, Read KD, Fairlamb AH. Target validation: linking target and chemical properties to desired product profile. Current Topics in Medicinal Chemistry (2011) Target identification and validation Abstract PMID: 21401506

Publications

Drug discovery and development

Begley CG, Ellis LM. Drug development: Raise standards for preclinical cancer research. Nature (2012) Drug discovery and development & Quality in research, robustness of data PMID: 22460880

Blair W, Cox C. Current Landscape of Antiviral Drug Discovery. F1000Research (2016) Drug discovery and development Abstract PMID: 26962437

Bunnage ME. Getting pharmaceutical R&D back on target. Nature Chemical Biology (2011) Target identification and validation & Drug discovery and development PMID: 21587251

Chadwick AT, Segall MD. Overcoming psychological barriers to good discovery decisions. Drug Discovery Today (2010) Drug discovery and development Abstract PMID: 20553956

Davis KD, Aghaeepour N, Ahn AH, Angst MS, Borsook D, Brenton A, Burczynski ME, Crean C, Edwards R, Gaudilliere B, Hergenroeder GW, Iadarola MJ, Iyengar S, Jiang Y, Kong JT, Mackey S, Saab CY, Sang CN, Scholz J, Segerdahl M, Tracey I, Veasley C, Wang J, Wager TD, Wasan AD, Pelleymounter MA. Discovery and validation of biomarkers to aid the development of safe and effective pain therapeutics: challenges and opportunities. Nature Reviews Neurology (2020) Drug discovery and development & Safety and toxicity Abstract PMID: 32541893

Dolgos H, Trusheim M, Gross D, Halle J-P, Ogden J, Osterwalder B, Sedman E, Rossetti L. Translational Medicine Guide transforms drug development processes: the recent Merck experience. Drug Discovery Today (2016) Drug discovery and development Abstract PMID: 26778693

Dowden H, Munro J. Trends in clinical success rates and therapeutic focus. Nature Reviews Drug Discovery (2019) Drug discovery and development Abstract PMID: 31267067

Egner U, Hillig RC. A structural biology view of target drugability. Expert Opinion on Drug Discovery (2008) Drug discovery and development Abstract PMID: 23489095

Ellinger B, Gribbon P. Risk mitigation in academic drug discovery. Expert Opinion on Drug Discovery (2016) Drug discovery and development PMID: 26894865

Everett JR. Academic drug discovery: current status and prospects. Expert Opinion on Drug Discovery (2015) Drug discovery and development Abstract PMID: 26088126

Frearson J, Wyatt P. Drug Discovery in Academia- the third way? Expert Opinion on Drug Discovery (2010) Drug discovery and development Abstract PMID: 20922062

Frye SV. Drug discovery in academic institutions. Hematology - American Society of Hematology - Education Program (2013) Drug discovery and development Abstract PMID: 24319195

Gashaw I, Ellinghaus P, Sommer A, Asadullah K. What makes a good drug target? Drug Discovery Today (2012) Target identification and validation & Drug discovery and development Abstract PMID: 22155646

Guengerich FP. Mechanisms of drug toxicity and relevance to pharmaceutical development. Drug Metabolism and Pharmacokinetics (2011) Drug discovery and development & Safety and toxicity Abstract PMID: 20978361

Hay M, Thomas DW, Craighead JL, Economides C, Rosenthal J. Clinical development success rates for investigational drugs. Nature Biotechnology (2014) Drug discovery and development PMID: 24406927

Herholt A, Galinski S, Geyer PE, Rossner MJ, Wehr MC. Multiparametric Assays for Accelerating Early Drug Discovery. Trends in Pharmacological Sciences (2020) Drug discovery and development Abstract PMID: 32223968

Hornberg JJ, Laursen M, Brenden N, Persson M, Thougaard AV, Toft DB, Mow T. Exploratory toxicology as an integrated part of drug discovery. Part I: Why and how. Drug Discovery Today (2014) Drug discovery and development & Safety and toxicity Abstract PMID: 24368175

Jekunen A. Decision-making in product portfolios of pharmaceutical research and development - managing streams of innovation in highly regulated markets. Drug Design, Development and Therapy (2014) Drug discovery and development & Commercialisation, partnering with industry Abstract PMID: 25364229

Kumar N, Sharma S, Kumar R, Tripathi BN, Barua S, Ly H, Rouse BT. Host-Directed Antiviral Therapy. Clinical Microbiology Reviews (2020) Drug discovery and development Abstract PMID: 32404434

Loregian A, Palù G. How academic labs can approach the drug discovery process as a way to synergize with big pharma. Trends in Microbiology (2013) Drug discovery and development Abstract PMID: 23731493

Morgan P, Brown DG, Lennard S, Anderton MJ, Barrett JC, Eriksson U, Fidock M, Hamrén B, Johnson A, March RE, Matcham J, Mettetal J, Nicholls DJ, Platz S, Rees S, Snowden MA, Pangalos MN. Impact of a five-dimensional framework on R&D productivity at AstraZeneca. Nature Reviews Drug Discovery (2018) Drug discovery and development Abstract PMID: 29348681

Perola E, Herman L, Weiss J. Development of a rule-based method for the assessment of protein druggability. Journal of Chemical Information and Modeling (2012) Drug discovery and development Abstract PMID: 22448735

Roy A. Challenges with risk mitigation in academic drug discovery: finding the best solution. Expert Opinion on Drug Discovery (2019) Drug discovery and development PMID: 30513005

Sams-Dodd F. Target-based drug discovery: is something wrong? Drug Discovery Today (2005) Target identification and validation & Drug discovery and development Abstract PMID: 15718163

Scannell JW, Bosley J. When Quality Beats Quantity: Decision Theory, Drug Discovery, and the Reproducibility Crisis. PLoS One (2016) Drug discovery and development Abstract PMID: 26863229

Singh SB, Young K, Silver LL. What is an "ideal" antibiotic? Discovery challenges and path forward. Biochemical Pharmacology (2017) Drug discovery and development Abstract PMID: 28087253

Strovel J, Sittampalam S, Coussens NP, Hughes M, Inglese J, Kurtz A, Andalibi A, Patton L, Austin C, Baltezor M, Beckloff M, Weingarten M, Weir S. Early Drug Discovery and Development Guidelines: For Academic Researchers, Collaborators, and Start-up Companies. Assay Guidance Manual (2004) Drug discovery and development & Guidelines and recommendations Abstract PMID: 22553881

Svennebring AM, Wikberg JES. Net present value approaches for drug discovery. Springerplus (2013) Drug discovery and development & Commercialisation, partnering with industry Abstract PMID: 23586005

Vamathevan JJ, Hall MD, Hasan S, Woollard PM, Xu M, Yang Y, Li X, Wang X, Kenny S, Brown JR, Huxley-Jones J, Lyon J, Haselden J, Min J, Sanseau P. Minipig and beagle animal model genomes aid species selection in pharmaceutical discovery and development. Toxicology and Applied Pharmacology (2013) Drug discovery and development Abstract PMID: 23602889

Verkman AS. Drug discovery in academia. American Journal of Physiology - Cell Physiology (2004) Drug discovery and development Abstract PMID: 14761879

Publications

Quality in research, robustness of data

Baker M. When antibodies mislead: the quest for validation. Nature (2020) Quality in research, robustness of data PMID: 32895531

Begley CG, Ellis LM. Drug development: Raise standards for preclinical cancer research. Nature (2012) Drug discovery and development & Quality in research, robustness of data PMID: 22460880

Button KS, Ioannidis JPA, Mokrysz C, Nosek BA, Flint J, Robinson ESJ, Munafò MR. Power failure: why small sample size undermines the reliability of neuroscience. Nature Reviews Neuroscience (2013) Quality in research, robustness of data Abstract PMID: 23571845

Cutter G. EFFECT size or statistical significance, where to put your money. Multiple Sclerosis and Related Disorders (2020) Quality in research, robustness of data Abstract PMID: 31715504

Dirnagl U. Rethinking research reproducibility. The EMBO Journal (2019) Quality in research, robustness of data PMID: 30518534

Dirnagl U. The p value wars (again). European Journal of Nuclear Medicine and Molecular Imaging (2019) Quality in research, robustness of data PMID: 31375858

Dirnagl U, Kurreck C, Castaños-Vélez E, Bernard R. Quality management for academic laboratories: burden or boon? Professional quality management could be very beneficial for academic research but needs to overcome specific caveats. EMBO Reports (2018) Quality in research, robustness of data PMID: 30341068

Drucker DJ. Never Waste a Good Crisis: Confronting Reproducibility in Translational Research. Cell Metabolism (2016) Quality in research, robustness of data & Guidelines and recommendations Abstract PMID: 27626191

du Sert NP, Ahluwalia A, Alam S, Avey MT, Baker M, Browne WJ, Clark A, Cuthill IC, Dirnagl U, Emerson M, Garner P, Holgate ST, Howells DW, Hurst V, Karp NA, Lazic SE, Lidster K, MacCallum CJ, Macleod M, Pearl EJ, Petersen OH, Rawle F, Reynolds P, Rooney K, Sena ES, Silberberg SD, Steckler T, Würbel H. Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 2.0. Plos Biology (2020) Quality in research, robustness of data Abstract PMID: 32663221

du Sert NP, Hurst V, Ahluwalia A, Alam S, Avey MT, Baker M, Browne WJ, Clark A, Cuthill IC, Dirnagl U, Emerson M, Garner P, Holgate ST, Howells DW, Karp NA, Lazic SE, Lidster K, MacCallum CJ, Macleod M, Pearl EJ, Petersen OH, Rawle F, Reynolds P, Rooney K, Sena ES, Silberberg SD, Steckler T, Würbel H. The ARRIVE guidelines 2.0: updated guidelines for reporting animal research. Plos Biology (2020) Quality in research, robustness of data Abstract PMID: 32666574

Freedman LP, Cockburn IM, Simcoe TS. The Economics of Reproducibility in Preclinical Research. PLoS Biology (2015) Quality in research, robustness of data Abstract PMID: 26057340

Frye SV, Arkin MR, Arrowsmith CH, Conn PJ, Glicksman MA, Hull-Ryde EA, Slusher BS. Tackling reproducibility in academic preclinical drug discovery. Nature Reviews. Nature Reviews Drug Discovery (2015) Quality in research, robustness of data Abstract PMID: 26388229

Galanopoulou AS, Buckmaster PS, Staley KJ, Moshé SL, Perucca E, Engel J, Löscher W, Noebels JL, Pitkänen A, Stables J, White HS, O'Brien TJ, Simonato M. Identification of new epilepsy treatments: issues in preclinical methodology. Epilepsia (2012) Quality in research, robustness of data & Guidelines and recommendations Abstract PMID: 22292566

Hartung T, Vries R de, Hoffmann S, Hogberg HT, Smirnova L, Tsaioun K, Whaley P, Leist M. Toward Good In Vitro Reporting Standards. ALTEX (2019) Quality in research, robustness of data & Guidelines and recommendations Abstract PMID: 30633302

Hooijmans CR, Leenaars M, Ritskes-Hoitinga M. A gold standard publication checklist to improve the quality of animal studies, to fully integrate the Three Rs, and to make systematic reviews more feasible. Alternatives to Laboratory Animals (2010) Quality in research, robustness of data Abstract PMID: 20507187

Ioannidis JPA. The Importance of Predefined Rules and Prespecified Statistical Analyses: Do Not Abandon Significance. JAMA (2019) Quality in research, robustness of data PMID: 30946431

Ioannidis JPA. How to make more published research true. PLoS Medicine (2014) Quality in research, robustness of data Abstract PMID: 25334033

Ioannidis JPA. Why most published research findings are false. PLoS Medicine (2005) Quality in research, robustness of data Abstract PMID: 16060722

Jarvis MF, Williams M. Irreproducibility in Preclinical Biomedical Research: Perceptions, Uncertainties, and Knowledge Gaps. Trends in Pharmacological Sciences (2016) Quality in research, robustness of data Abstract PMID: 26776451

Jasny BR, Wigginton N, McNutt M, Bubela T, Buck S, Cook-Deegan R, Gardner T, Hanson B, Hustad C, Kiermer V, Lazer D, Lupia A, Manrai A, McConnell L, Noonan K, Phimister E, Simon B, Strandburg K, Summers Z, Watts D. Fostering reproducibility in industry-academia research. Science (2017) Quality in research, robustness of data PMID: 28839064

Kaplan RM, Irvin VL. Likelihood of Null Effects of Large NHLBI Clinical Trials Has Increased over Time. PLoS One (2015) Quality in research, robustness of data Abstract PMID: 26244868

Kilkenny C, Parsons N, Kadyszewski E, Festing MFW, Cuthill IC, Fry D, Hutton J, Altman DG. Survey of the quality of experimental design, statistical analysis and reporting of research using animals. PLoS One (2009) Quality in research, robustness of data Abstract PMID: 19956596

Kimmelman J, Mogil JS, Dirnagl U. Distinguishing between exploratory and confirmatory preclinical research will improve translation. PLoS Biology (2014) Quality in research, robustness of data Abstract PMID: 24844265

Kumar K. Good Documentation Practices (GDPs) in Pharmaceutical Industry. Journal of Analytical & Pharmaceutical Research (2017) Quality in research, robustness of data Link

Kurreck C, Castaños-Vélez E, Freyer D, Blumenau S, Przesdzing I, Bernard R, Dirnagl U. Improving quality of preclinical academic research through auditing: A feasibility study. PLoS One (2020) Quality in research, robustness of data Abstract PMID: 33057427

Lazic SE, Clarke-Williams CJ, Munafò MR. What exactly is 'N' in cell culture and animal experiments? PLoS Biology (2018) Quality in research, robustness of data & Guidelines and recommendations Abstract PMID: 29617358

Leist M, Efremova L, Karreman C. Food for thought...considerations and guidelines for basic test method descriptions in toxicology. ALTEX (2010) Quality in research, robustness of data & Guidelines and recommendations Abstract PMID: 21240472

Macleod MR. Findings of a retrospective, controlled cohort study of the impact of a change in Nature journals' editorial policy for life sciences research on the completeness of reporting study design and execution. bioRxiv - The Preprint Server for Biology (2017) Quality in research, robustness of data Link

Macleod MR, Michie S, Roberts I, Dirnagl U, Chalmers I, Ioannidis JPA, Salman RA-S, Chan A-W, Glasziou P. Biomedical research: increasing value, reducing waste. The Lancet (2014) Quality in research, robustness of data PMID: 24411643

Macleod MR, van der Worp HB, Sena ES, Howells DW, Dirnagl U, Donnan GA. Evidence for the efficacy of NXY-059 in experimental focal cerebral ischaemia is confounded by study quality. Stroke (2008) Quality in research, robustness of data Abstract PMID: 18635842

Menke J, Roelandse M, Ozyurt B, Martone M, Bandrowski A. Rigor and Transparency Index, a new metric of quality for assessing biological and medical science methods. bioRxiv (2020) Quality in research, robustness of data Link

Moonesinghe R, Khoury MJ, Janssens ACJW. Most published research findings are false-but a little replication goes a long way. PLoS Medicine (2007) Quality in research, robustness of data PMID: 17326704

Motulsky HJ. Common misconceptions about data analysis and statistics. Naunyn-Schmiedeberg's Archives of Pharmacology (2014) Quality in research, robustness of data Abstract PMID: 25213136

Perrier L, Blondal E, Ayala AP, Dearborn D, Kenny T, Lightfoot D, Reka R, Thuna M, Trimble L, MacDonald H. Research data management in academic institutions: A scoping review. PLoS One (2017) Quality in research, robustness of data Abstract PMID: 28542450

Perrin S. Preclinical research: Make mouse studies work. Nature News (2014) Quality in research, robustness of data Link

Phillips CV, Goodman KJ. The missed lessons of Sir Austin Bradford Hill. Epidemiologic Perspectives & Innovations (2004) Quality in research, robustness of data Abstract PMID: 15507128

Rattan AK. Data Integrity: History, Issues, and Remediation of Issues. PDA Journal of Pharmaceutical Science and Technology (2018) Quality in research, robustness of data Abstract PMID: 29158286

Richter SH, Garner JP, Zipser B, Lewejohann L, Sachser N, Touma C, Schindler B, Chourbaji S, Brandwein C, Gass P, van Stipdonk N, van der Harst J, Spruijt B, Võikar V, Wolfer DP, Würbel H. Effect of population heterogenization on the reproducibility of mouse behavior: a multi-laboratory study. PLoS One (2011) Quality in research, robustness of data Abstract PMID: 21305027

Scott S, Kranz JE, Cole J, Lincecum JM, Thompson K, Kelly N, Bostrom A, Theodoss J, Al-Nakhala BM, Vieira FG, Ramasubbu J, Heywood JA. Design, power, and interpretation of studies in the standard murine model of ALS. Amyotrophic Lateral Sclerosis (2008) Quality in research, robustness of data Abstract PMID: 18273714

Steward O. A Rhumba of "R's": Replication, Reproducibility, Rigor, Robustness: What Does a Failure to Replicate Mean? eNeuro (2016) Quality in research, robustness of data PMID: 27419220

Steward O, Balice-Gordon R. Rigor or mortis: best practices for preclinical research in neuroscience. Neuron (2014) Quality in research, robustness of data Abstract PMID: 25442936

Sullivan GM, Feinn R. Using Effect Size-or Why the P Value Is Not Enough. Journal of Graduate Medical Education (2012) Quality in research, robustness of data PMID: 23997866

Vollert J, Schenker E, Macleod M, Bespalov A, Wuerbel H, Michel M, Dirnagl U, Potschka H, Waldron AM, Wever K, Steckler T, van de Casteele T, Altevogt B, Sil A, Rice ASC, The EQIPD WP3 study group members. Systematic review of guidelines for internal validity in the design, conduct and analysis of preclinical biomedical experiments involving laboratory animals. BMJ Open Science (2020) Quality in research, robustness of data & Guidelines and recommendations Link

Wasserstein RL, Schirm AL, Lazar NA. Moving to a World Beyond "p < 0.05". The American Statistician (2019) Quality in research, robustness of data Link

Wilkinson MD, Dumontier M, Aalbersberg IJ, Appleton G, Axton M, Baak A, Blomberg N, Boiten JW, da Silva Santos LB, Bourne PE, Bouwman J, Brookes AJ, Clark T, Crosas M, Dillo I, Dumon O, Edmunds S, Evelo CT, Finkers R, Gonzalez-Beltran A, Gray AJ, Groth P, Goble C, Grethe JS, Heringa J, 't Hoen PA, Hooft R, Kuhn T, Kok R, Kok J, Lusher SJ, Martone ME, Mons A, Packer AL, Persson B, Rocca-Serra P, Roos M, van Schaik R, Sansone SA, Schultes E, Sengstag T, Slater T, Strawn G, Swertz MA, Thompson M, van der Lei J, van Mulligen E, Velterop J, Waagmeester A, Wittenburg P, Wolstencroft K, Zhao J, Mons B. The FAIR Guiding Principles for scientific data management and stewardship. Scientific Data (2016) Quality in research, robustness of data Abstract PMID: 26978244

Williams M. Reagent Validation to Facilitate Experimental Reproducibility. Curr Protocols in Pharmacology (2018) Quality in research, robustness of data PMID: 29927084

Witowski J, Sikorska D, Rudolf A, Miechowicz I, Kamhieh-Milz J, JWörbelrres A, Bręborowicz A. Quality of design and reporting of animal research in peritoneal dialysis: A scoping review. SAGE Journals (2020) Quality in research, robustness of datat Abstract PMID: 32063215

Zhang N, Chung N, Oldenburg N. A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays. Journal of Biomolecular Screening (1999) Quality in research, robustness of data Abstract PMID: 10838414

Publications

Guidelines and recommendations

Baker D, Lidster K, Sottomayor A, Amor S. Two years later: journals are not yet enforcing the ARRIVE guidelines on reporting standards for pre-clinical animal studies. PLoS Biology (2014) Guidelines and recommendations Abstract PMID: 24409096

Bespalov A, Steckler T, Skolnick P. Be positive about negatives-recommendations for the publication of negative (or null) results. European Neuropsychopharmacology (2019) Guidelines and recommendations Abstract PMID: 31753777

Emmerich CE, Martinez-Gamboa L, Hofmann MCJ, Bonin-Andresen M, Arbach O, Schendel P, Gerlach B, Hempel K, Bespalov A, Dirnagl U, Parnham MJ. Improving target assessment in biomedical research: the GOT-IT recommendations. Nature Reviews Drug Discovery (2020) Guidelines and recommendations Abstract PMID: 33199880

Gosselin RD. Guidelines on statistics for researchers using laboratory animals: the essentials. Laboratory Animals (2019) Guidelines and recommendations Abstract PMID: 29954248

Jenkinson S, Schmidt F, Ribeiro LR, Delaunois A, Valentin JP. A practical guide to secondary pharmacology in drug discovery. Journal of Pharmacological and Toxicological Methods (2020) Guidelines and recommendations & Safety and toxicity Abstract PMID: 32302774

Kilkenny C, Browne WJ, Cuthill IC, Emerson M, Altman DG. Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research. PLoS Biology (2010) Guidelines and recommendations PMID: 20613859

Landis SC, Amara SG, Asadullah K, Austin CP, Blumenstein R, Bradley EW, Crystal RG, Darnell RB, Ferrante RJ, Fillit H, Finkelstein R, Fisher M, Gendelman HE, Golub RM, Goudreau JL, Gross RA, Gubitz AK, Hesterlee SE, Howells DW, Huguenard J, Kelner K, Koroshetz W, Krainc D, Lazic SE, Levine MS, Macleod MR, McCall JM, Moxley RT 3rd, Narasimhan K, Noble LJ, Perrin S, Porter JD, Steward O, Unger E, Utz U, Silberberg SD. A call for transparent reporting to optimize the predictive value of preclinical research. Nature (2012) Guidelines and recommendations Abstract PMID: 23060188

Mansi BA, Clark J, David FS, Gesell TM, Glasser S, Gonzalez J, Haller DG, Laine C, Miller CL, Mooney LA, Zecevic M. Ten recommendations for closing the credibility gap in reporting industry-sponsored clinical research: a joint journal and pharmaceutical industry perspective. Mayo Clinic Proceedings (2012) Guidelines and recommendations PMID: 22560521

McGrath JC, Drummond GB, McLachlan EM, Kilkenny C, Wainwright CL. Guidelines for reporting experiments involving animals: the ARRIVE guidelines. British Journal of Pharmacology (2010) Guidelines and recommendations Abstract PMID: 20649560

Michel MC, Murphy TJ, Motulsky HJ. New Author Guidelines for Displaying Data and Reporting Data Analysis and Statistical Methods in Experimental Biology. Molecular Pharmacology (2020) Guidelines and recommendations Abstract PMID: 31882404

Moher D, Shamseer L, Clarke M, Ghersi D, Liberati A, Petticrew M, Shekelle P, Stewart LA, PRISMA-P Group. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Systematic Reviews (2015) Guidelines and recommendations Abstract PMID: 25554246

Moore CG, Carter RE, Nietert PJ, Stewart PW. Recommendations for planning pilot studies in clinical and translational research. Clinical and Translational Science (2011) Guidelines and recommendations Abstract PMID: 22029804

Morant AV, Vestergaard HT, Lassen AB, Navikas V. US, EU, and Japanese Regulatory Guidelines for Development of Drugs for Treatment of Alzheimer's Disease: Implications for Global Drug Development. Clinical and Translational Science (2020) Guidelines and recommendations Abstract PMID: 32043310

Percie du Sert N, Hurst V, Ahluwalia A, Alam S, Avey MT, Baker M, Browne WJ, Clark A, Cuthill IC, Dirnagl U, Emerson M, Garner P, Holgate ST, Howells DW, Karp NA, Lidster K, MacCallum CJ, Macleod M, Petersen O, Rawle F, Reynolds P, Rooney K, Sena ES, Silberberg SD, Steckler T, Würbel H. The ARRIVE guidelines 2019: updated guidelines for reporting animal research. bioRxiv - The Preprint Server for Biology (2019) Guidelines and recommendations Link

Sansone S-A, McQuilton P, Rocca-Serra P, Gonzalez-Beltran A, Izzo M, Lister AL, Thurston M. FAIRsharing as a community approach to standards, repositories and policies. Nature Biotechnology (2019) Guidelines and recommendations PMID: 30940948

Strech D, Weissgerber T, Dirnagl U, QUEST Group. Improving the trustworthiness, usefulness, and ethics of biomedical research through an innovative and comprehensive institutional initiative. PLoS Biology (2020) Guidelines and recommendations Abstract PMID: 32045410

Publications

Commercialisation, partnering with industry

Bergeron S, Grant JL. Validity studies-enhancing patent searches. Pharmaceutical Patent Analyst (2016) Commercialisation, partnering with industry PMID: 27813443

Bohrer RA. Reach-through claims for drug target patents: Rx for pharmaceutical policy. Nature Biotechnology (2008) Commercialisation, partnering with industry PMID: 18183015

Edwards A. Reproducibility: Team up with industry. Nature (2016) Commercialisation, partnering with industry PMID: 26983524

Gehr S, Garner CC. Rescuing the Lost in Translation. Cell (2016) Commercialisation, partnering with industry Abstract PMID: 27153487

Goldstein JA. Patenting the tools of drug discovery. Drug Discovery World (2019) Commercialisation, partnering with industry Link

Rosenblatt M. How academia and the pharmaceutical industry can work together: the president's lecture, annual meeting of the American Thoracic Society, San Francisco, California. Annals of the American Thoracic Society (2013) Commercialisation, partnering with industry Abstract PMID: 23509330

Stewart JJ, Allison PN, Johnson RS. Putting a price on biotechnology. Nature Biotechnology (2001) Commercialisation, partnering with industry PMID: 11533634

Svennebring AM, Wikberg JES. Net present value approaches for drug discovery. Springerplus (2013) Drug discovery and development & Commercialisation, partnering with industry Abstract PMID: 23586005

Tralau-Stewart CJ, Wyatt CA, Kleyn DE, Ayad A. Drug discovery: new models for industry-academic partnerships. Drug Discovery Today (2009) Commercialisation, partnering with industry Abstract PMID: 18992364

Yu HWH. Bridging the translational gap: collaborative drug development and dispelling the stigma of commercialization. Drug Discovery Today (2016) Commercialisation, partnering with industry Abstract PMID: 26546858

Publications

Safety and toxicity

Bhoumik P, Del Rio-Espinola A, Hahne F, Moggs J, Grenet O. Translational Safety Genetics. Toxicologic Pathology (2017) Safety and toxicity Abstract PMID: 27932582

Ciesielski TH, Pendergrass SA, White MJ, Kodaman N, Sobota RS, Huang M, Bartlett J, Li J, Pan Q, Gui J, Selleck SB, Amos CI, Ritchie MD, Moore JH, Williams SM. Diverse convergent evidence in the genetic analysis of complex disease: coordinating omic, informatic, and experimental evidence to better identify and validate risk factors. BioData Mining (2014) Safety and toxicity Abstract PMID: 25071867

Lin A, Giuliano CJ, Palladino A, John KM, Abramowicz C, Yuan ML, Sausville EL, Lukow DA, Liu L, Chait AR, Galluzzo ZC, Tucker C, Sheltzer JM. Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials. Science Translational Medicine (2019) Safety and toxicity Abstract PMID: 31511426

Mellor HR, Bell AR, Valentin J-P, Roberts RRA. Cardiotoxicity associated with targeting kinase pathways in cancer. Toxicol. Sciences (2011) Safety and toxicity Abstract PMID: 21177772

Olson H, Betton G, Robinson D, Thomas K, Monro A, Kolaja G, Lilly P, Sanders J, Sipes G, Bracken W, Dorato M, van Deun K, Smith P, Berger B, Heller A. Concordance of the toxicity of pharmaceuticals in humans and in animals. Regulatory Toxicology and Pharmacology (2000) Safety and toxicity Abstract PMID: 11029269

Reynolds VL, Butler P, Abernathy MM, Aschenbrenner L, Best DD, Blank J, Crosby M, Custer L, Escobar PA, Kolaja K, Moggs J, Shuey D, Snyder C, Van Vleet T, Zhou J, Hart TK. Nonclinical safety assessment of epigenetic modulatory drugs: Current status and industry perspective. Regulatory Toxicology and Pharmacology (2020) Safety and toxicity Abstract PMID: 32911461

Rudmann DG. On-target and off-target-based toxicologic effects. Toxicologic Pathology (2013) Safety and toxicity Abstract PMID: 23085982

Sahota T, Danhof M, Della Pasqua O. Pharmacology-based toxicity assessment: towards quantitative risk prediction in humans. Mutagenesis (2016) Safety and toxicity Abstract PMID: 26970519

Xu JJ, Urban L. Predictive Toxicology in Drug Safety. Cambridge University Press (2010) Safety and toxicity Link

Publications

Other

von Bonin A, Rausch A, Mengel A, Hitchcock M, Krüger M, von Ahsen O, Merz C, Röse L, Stock C, Martin SF, Leder G, Döcke WD, Asadullah K, Zügel U. Inhibition of the IL-2-inducible tyrosine kinase (Itk) activity: a new concept for the therapy of inflammatory skin diseases. Experimental Dermatology (2011) Other Abstract PMID: 21158938

Madak JT, Bankhead A III, Cuthbertson CR, Showalter HD, Neamati N. Revisiting the role of dihydroorotate dehydrogenase as a therapeutic target for cancer. Pharmacology & Therapeutics (2019) Other Abstract PMID: 30347213

Fukushima R, Kanamori S, Hirashiba M, Hishikawa A, Muranaka R, Kaneto M, Kitagawa H. Inhibiting the teratogenicity of the immunosuppressant leflunomide in mice by supplementation of exogenous uridine. Toxicological Sciences (2009) Other Abstract PMID: 19190124

Ng SB, Buckingham KJ, Lee C, Bigham AW, Tabor HK, Dent KM, Huff CD, Shannon PT, Jabs EW, Nickerson DA, Shendure J, Bamshad MJ. Exome sequencing identifies the cause of a mendelian disorder. Nature Genetics (2009) Other Abstract PMID: 19915526

Sam AH, Salem V, Ghatei MA. Rimonabant: From RIO to Ban. Journal of Obesity (2011) Other Abstract PMID: 21773005

Publications

Abstracts/Posters

British Pharmacological Society Meeting 2019

Parnham M, Emmerich CH, Martinez-Gamboa L, Hofmann M, Bespalov A, Dirnagl U. GOT-IT - Guidelines on Target Assessment for Innovative Therapeutics. (Abstract / Poster)

6. WCRI (World Conference on Research Integrity) 2019

Emmerich CH, Martinez-Gamboa L, Gerlach B, Bespalov A, Hofmann M, Bonin-Andresen M, Schendel P, Parnham M, Dirnagl U. GOT-IT - Guidelines on Target Assessment for Innovative Therapeutics. (Abstract / Poster)

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Publications

All Publications